Drug Pipeline

CCM Bio drug programs are organized in single- or multi-asset corporate subsidiaries, enabling flexible partnership opportunities

CCM Protein Upregulation CCM 5Prime Sciences

CCM Protein Upregulation

PROGRAM
CANDIDATE
INDICATIONS
HIT-TO-LEAD
LEAD OPTIMIZATION
IND ENABLING
CLINICAL
Nonsense Mutations
CCM-848, 914, 930
Cystic Fibrosis
Duchenne Muscular Dystrophy
Sirtuin
CCM-SRX
In-vitro maturation
In-vitro fertilisation
Parkinson's
Alzheimer's

CCM 5Prime Sciences

Oncology and Autoimmune Companion Diagnostic (CDx) Pipeline

TARGET MUTATION
COMPANION THERAPEUTICS
Cdx IP
HIT-TO-LEAD
LEAD OPTIMIZATION
IND ENABLING
CLINICAL
KRAS G12V
CCM-001
CCM-MRX
1. Bias-free NGS
2. FADS PCR
1. Bias-free NGS
2. FADS PCR
ROS1 / Trk Fusions
CCM-TRX
1. Bias-free NGS
2. FADS PCR
FLT3 Fusions
CCM-FLX
1. Bias-free NGS
2. FADS PCR
EGFR: 1. T790M/L858R 2. T790M/L858R/C797S 3. T790M/Exon 20 4. T790M/del19/C797S
CCM-EGX
1. Bias-free NGS
2. FADS PCR
EGFR: 1. EGFRvIII 2. EGFR overexpression
Fast, robust FADS PCR
Panel of 134 Fibrosis-associated Genes
CCM-7314, CCM-7560
Bias-free NGS

Prenatal IVD Pipeline

TARGET MUTATION
COMPANION THERAPEUTICS
Cdx IP
HIT-TO-LEAD
LEAD OPTIMIZATION
IND ENABLING
CLINICAL
Preimplantation embryo aneuploidy
CCM-SRX
Noninvasive pre-implantation genetic testing
Triplet Repeat Disease (Autism-Fragile X)
NA
Nonsense Mutation
CCM-848,914,930 (Codagen)
Highly processive polymerase + GC-rich PCR